Drug Combination Details
| General Information of the Combination (ID: C06543) | |||||
|---|---|---|---|---|---|
| Name | Phloretin NP Info | + | Duloxetine Drug Info | ||
| Structure |
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+ |
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| Disease |
Diabetic neuropathy
[ICD-11: 8C03]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Decreasing Adverse Drug Reaction by This Combination | ||||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | Diabetic neuropathy (DN) rat models were used in this study. | |||||
| Experimental
Result(s) |
DX augmented the DM metabolic disturbance and hepatic dysfunction, however, PH effectively amended these disorders. The low-dose combination of both, had the merits of both medications, with the alleviation of their disadvantages. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Phloretin either alone or in combination with duloxetine alleviates the STZ-induced diabetic neuropathy in rats. Biomed Pharmacother. 2018 May;101:821-832. | |||
