Drug Combination Details
General Information of the Combination (ID: C06615) | |||||
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Name | Capsaicin NP Info | + | 5-fluorouracil Drug Info | ||
Structure |
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Disease |
Hepatocellular carcinoma
[ICD-11: 2C12]
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Investigative | [1] |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. Enhancing Drug Efficacy by This Combination | ||||||
Achieving Therapeutic Synergy | Click to Show/Hide | |||||
Experiment 1 Reporting the Effect of This Combination | [1] | |||||
Molecule(s)
Regulation |
Up-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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Down-regulation | Expression | ATG3 | Molecule Info |
Pathway MAP
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Down-regulation | Expression | BECN1 | Molecule Info |
Pathway MAP
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Up-regulation | Expression | MAP1LC3A | Molecule Info |
Pathway MAP
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Up-regulation | Phosphorylation | S6K1 | Molecule Info |
Pathway MAP
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In-vitro Model | QBC939 | CVCL_6942 | Cholangiocarcinoma | Homo sapiens | ||
SK-ChA-1 | CVCL_6952 | Cholangiocarcinoma | Homo sapiens | |||
Mz-ChA-1 | CVCL_6932 | Gallbladder carcinoma | Homo sapiens | |||
Experimental
Result(s) |
Capsaicin enhances 5FU sensitivity of cholangiocarcinoma through the inhibition of 5FU-induced autophagy by activating the PI3K/AKT/mTOR pathway. |
References | ||||
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Reference 1 | Capsaicin Enhances the Drug Sensitivity of Cholangiocarcinoma through the Inhibition of Chemotherapeutic-Induced Autophagy. PLoS One. 2015 May 1;10(5):e0121538. |
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