Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
α. Enhancing Drug Efficacy by This Combination |
Achieving Therapeutic Synergy |
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Experiment 1 Reporting the Effect of This Combination |
[1] |
In-vitro Model |
NCI-N87 |
CVCL_1603
|
Gastric tubular adenocarcinoma |
Homo sapiens |
BGC-823 |
CVCL_3360
|
Gastric cancer |
Homo sapiens |
SNU-16 |
CVCL_0076
|
Gastric adenocarcinoma |
Homo sapiens |
SGC-7901 |
CVCL_0520
|
Human gastric cancer |
Homo sapiens |
MGC-803 |
CVCL_5334
|
Gastric mucinous adenocarcinoma |
Homo sapiens |
In-vivo Model |
Female BALB/c nude mice (4-5 weeks old) were subcutaneously injected with 1*107 NCI-N87 cells (suspended in 100 ul of PBS with 50% Matrigel) to establish tumors. |
Experimental
Result(s) |
Cucurbitacin E inhibits cellular proliferation and enhances the chemo-response in gastric cancer by suppressing AKt activation. |