Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
α. Enhancing Drug Efficacy by This Combination |
Achieving Therapeutic Synergy |
Click to Show/Hide |
Experiment 1 Reporting the Effect of This Combination |
[1] |
In-vivo Model |
The co-treatment of the carcinogen 4-NQO (200 ug/ml) plus arecoline (500 ug/ml) in the drinking water for eight weeks to C57BL-6 mice specifically induced tongue cancer within a further 20 weeks. |
Experimental
Result(s) |
Arsenic trioxide plus dithiothreitol showed synergistic cytotoxic effects on mice oral cancer cells. |