Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
α. Enhancing Drug Efficacy by This Combination |
Achieving Therapeutic Synergy |
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Experiment 1 Reporting the Effect of This Combination |
[1] |
In-vitro Model |
Ba/F3 |
CVCL_0161
|
Healthy |
Mus musculus |
WEHI-265.1 |
CVCL_3620
|
Mouse leukemia |
Mus musculus |
In-vivo Model |
Ba/F3-insH cell line xenografts were generated by injecting 5*106 cells in 50% matrigel into six-to eight- week old male nu/nu nude mice. |
Experimental
Result(s) |
The combination of ellagic acid with erlotinib has synergistic effects against EGFR H773_V774 insH mutation. |