Drug Combination Details
General Information of the Combination (ID: C36464) | |||||
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Name | Curcumin NP Info | + | ABT-888 Drug Info | ||
Structure | + | ||||
Disease |
Breast cancer
[ICD-11: 2C60]
|
Investigative | [1] |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. Enhancing Drug Efficacy by This Combination | ||||||
Augmenting Drug Sensitivity | Click to Show/Hide | |||||
Experiment 1 Reporting the Effect of This Combination | [1] | |||||
Molecule(s)
Regulation |
Up-regulation | Expression | H2AFX | Molecule Info |
Pathway MAP
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Down-regulation | Expression | RAD51 | Molecule Info |
Pathway MAP
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In-vitro Model | MDA-MB-231 | CVCL_0062 | Breast adenocarcinoma | Homo sapiens | ||
MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | |||
U2OS | CVCL_0042 | Osteosarcoma | Homo sapiens | |||
In-vivo Model | 2*106 human MDA-MB-231 cells were prepared with 200 uL of PBS/matrigel gel (1:1 ratio) and injected subcutaneously into the flanks of athymic nude mice (two-site injections). | |||||
Experimental
Result(s) |
Curcumin enhances poly(ADP-ribose) polymerase inhibitor sensitivity to chemotherapy in breast cancer cells. |
References | ||||
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Reference 1 | Curcumin enhances poly(ADP-ribose) polymerase inhibitor sensitivity to chemotherapy in breast cancer cells. J Nutr Biochem. 2015 Dec;26(12):1442-7. |