| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
| α. Enhancing Drug Efficacy by This Combination |
| Achieving Therapeutic Synergy |
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| Experiment 1 Reporting the Effect of This Combination |
[1] |
| In-vivo Model |
Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) (60 mg/kg) in rat. |
Experimental
Result(s) |
The combined therapy of losartan and L-carnitine affords additive beneficial effects against diabetes-associated endothelial dysfunction, possibly via normalizing the dysregulated eNOS and reducing the inflammation and oxidative stress in diabetic rats. |
