Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
α. Enhancing Drug Efficacy by This Combination |
Achieving Therapeutic Synergy |
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Experiment 1 Reporting the Effect of This Combination |
[1] |
In-vitro Model |
Cells derived from glioblastoma multiforme patients |
Glioblastoma multiforme |
Homo sapiens |
In-vivo Model |
For in vivo experiments, CSCs (5 * 104 cells) were implanted intracranially into 10 week-old female C.B17-lcr SCID mice. |
Experimental
Result(s) |
Arsenic trioxide drastically enhanced the anti-proliferative effect of 10058F4 but not apoptotic effects. |