Drug Combination Details
General Information of the Combination (ID: C54208) | |||||
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Name | Epigallocatechin gallate NP Info | + | SU5416 Drug Info | ||
Structure | + | ||||
Disease |
Adrenocortical carcinoma
[ICD-11: 2D11]
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Investigative | [1] |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. Enhancing Drug Efficacy by This Combination | ||||||
Achieving Therapeutic Synergy | Click to Show/Hide | |||||
Experiment 1 Reporting the Effect of This Combination | [1] | |||||
Molecule(s)
Regulation |
Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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Down-regulation | Expression | CDK2 | Molecule Info |
Pathway MAP
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Up-regulation | Expression | CDKN1A | Molecule Info |
Pathway MAP
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Down-regulation | Expression | EGFR | Molecule Info |
Pathway MAP
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Down-regulation | Expression | FGF2 | Molecule Info |
Pathway MAP
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Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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Down-regulation | Expression | VEGFA | Molecule Info |
Pathway MAP
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In-vitro Model | SH-SY5Y | CVCL_0019 | Neuroblastoma | Homo sapiens | ||
SK-N-BE(2) | CVCL_0528 | Neuroblastoma | Homo sapiens | |||
Experimental
Result(s) |
SU5416 and EGCG work synergistically and inhibit angiogenic and survival factors and induce cell cycle arrest to promote apoptosis in human malignant neuroblastoma SH-SY5Y and SK-N-BE2 cells. |