Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
α. Enhancing Drug Efficacy by This Combination |
Achieving Therapeutic Synergy |
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Experiment 1 Reporting the Effect of This Combination |
[1] |
In-vitro Model |
K-562 |
CVCL_0004
|
Chronic myelogenous leukemia |
Homo sapiens |
In-vivo Model |
For a xenograft model, 1*109 human K562 cells were injected into the inguinal mammary fat pad of Balb/c congenic athymic nude mice. |
Experimental
Result(s) |
An important role for VSTM1 in the pathogenesis of leukemia, and SG611-VSTM1 may be a promising agent for enhancing chemosensitivity in leukemia therapy. |