Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
α. Enhancing Drug Efficacy by This Combination |
Achieving Therapeutic Synergy |
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Experiment 1 Reporting the Effect of This Combination |
[1] |
In-vitro Model |
FCCH1043 |
CVCL_M518
|
Adult T acute lymphoblastic leukemia |
Homo sapiens |
MT-2 |
CVCL_2631
|
Healthy |
Homo sapiens |
HuT 102 |
CVCL_3526
|
Mycosis fungoides and Sezary syndrome |
Homo sapiens |
In-vivo Model |
The xenograft model was established by intraperitoneal injection of 1.5*107 MET-1 cells into SCID/NOD mice. |
Experimental
Result(s) |
Combination of the flavopiridol and anti-CD25 monoclonal antibody dramatically enhanced the antitumor effect. |