Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
α. Enhancing Drug Efficacy by This Combination |
Achieving Therapeutic Synergy |
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Experiment 1 Reporting the Effect of This Combination |
[1] |
In-vitro Model |
HeLa |
CVCL_0030
|
Endocervical adenocarcinoma |
Homo sapiens |
Ca Ski |
CVCL_1100
|
Cervical squamous cell carcinoma |
Homo sapiens |
SiHa |
CVCL_0032
|
Cervical squamous cell carcinoma |
Homo sapiens |
C-33 A |
CVCL_1094
|
Cervical squamous cell carcinoma |
Homo sapiens |
Experimental
Result(s) |
Cisplatin and Caffeic acid in combination synergistically inhibited the growth of cells and induced apoptosis in HeLa and CaSki cells. The mechanism that is most likely to be behind the efficacy of this treatment is the modulation of apoptosis-regulated expression. |