Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
α. Enhancing Drug Efficacy by This Combination |
Achieving Therapeutic Synergy |
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Experiment 1 Reporting the Effect of This Combination |
[1] |
In-vitro Model |
Rh18 |
CVCL_1659
|
Alveolar rhabdomyosarcoma |
Homo sapiens |
D283 Med |
CVCL_1155
|
Medulloblastoma |
Homo sapiens |
Daoy |
CVCL_1167
|
Medulloblastoma |
Homo sapiens |
SJ-GBM2 |
CVCL_M141
|
Glioblastoma |
Homo sapiens |
NB-EB |
Neuroblastoma |
Homo sapiens |
RMSs |
Embryonal rhabdomyosarcoma |
Homo sapiens |
Experimental
Result(s) |
The therapeutic effect of combining topotecan with vincristine was greater than additive in most tumor models of childhood solid tumors tested. |