Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
α. Decreasing Adverse Drug Reaction by This Combination |
Decreasing Adverse Drug Reaction |
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Experiment 1 Reporting the Effect of This Combination |
[1] |
In-vivo Model |
Male C57BL/6 mice between 8-10 weeks were injected with DMSO, 15 mg/kg doxorubicin, or doxorubicin plus 25 mg/kg visnagin or 10 mg/kg diphenylurea intraperitoneally (n=4-5 each). |
Experimental
Result(s) |
There are synergistic antioxidative effects among the antioxidants, SAMe and vitamins C and E, that protect the liver from TAA-induced HDIR, suggesting that antioxidant treatment may best be done using a balanced "cocktail.". |