Drug Combination Details
General Information of the Combination (ID: C74319) | |||||
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Name | Rhein NP Info | + | Calphostin c Drug Info | ||
Structure | + | ||||
Disease |
Colon cancer
[ICD-11: 2B90]
|
Investigative | [1] |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. Enhancing Drug Efficacy by This Combination | ||||||
Achieving Therapeutic Synergy | Click to Show/Hide | |||||
Experiment 1 Reporting the Effect of This Combination | [1] | |||||
Molecule(s)
Regulation |
Down-regulation | Expression | XIAP | Molecule Info |
Pathway MAP
|
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In-vitro Model | HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | ||
RKO | CVCL_0504 | Colon carcinoma | Homo sapiens | |||
Experimental
Result(s) |
Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. |