Drug Combination Details
General Information of the Combination (ID: C78370) | |||||
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Name | Curdione NP Info | + | Doxorubicin Drug Info | ||
Structure | + | ||||
Disease |
Healthy individual
[ICD-11: N.A.]
|
Investigative | [1] |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. Decreasing Adverse Drug Reaction by This Combination | ||||||
Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
Experiment 1 Reporting the Effect of This Combination | [1] | |||||
Molecule(s)
Regulation |
Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
|
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In-vitro Model | H9c2(2-1) | CVCL_0286 | Healthy | Rattus norvegicus | ||
Experimental
Result(s) |
Curdione ameliorated doxorubicin-induced cardiotoxicity through suppressing oxidative stress and activating Nrf2/HO-1 pathway. |
References | ||||
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Reference 1 | Curdione Ameliorated Doxorubicin-Induced Cardiotoxicity Through Suppressing Oxidative Stress and Activating Nrf2/HO-1 Pathway. J Cardiovasc Pharmacol. 2019 Aug;74(2):118-127. |