Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
α. Enhancing Drug Efficacy by This Combination |
Achieving Therapeutic Synergy |
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Experiment 1 Reporting the Effect of This Combination |
[1] |
In-vitro Model |
U-87MG ATCC |
CVCL_0022
|
Glioblastoma |
Homo sapiens |
T98G |
CVCL_0556
|
Glioblastoma |
Homo sapiens |
HG19 cells isolated from brain tumor biopsies |
Brain tumor |
Homo sapiens |
In-vivo Model |
Tumors were induced in nude mice by subcutaneous injection of 5 * 106 U87 cells or 10 *106 T98 cells in PBS supplemented with 0.1% glucose. |
Experimental
Result(s) |
The combined administration of Delta(9)-Tetrahydrocannabinol and temozolomide exerts a strong antitumoral action in glioma xenografts, an effect that is also observed in tumors that are resistant to TMZ treatment. |