Drug Combination Details
General Information of the Combination (ID: C80540) | |||||
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Name | L-arginine | + | Phentolamine + Sildenafil | ||
Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
Name | L-arginine NP Info | Drug Info | |||
Structure | |||||
Name | Drug Info | ||||
Structure | |||||
Disease |
Erectile dysfunction
[ICD-11: HA01]
|
Investigative | [1] |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. Enhancing Drug Efficacy by This Combination | ||||||
Achieving Therapeutic Synergy | Click to Show/Hide | |||||
Experiment 1 Reporting the Effect of This Combination | [1] | |||||
Biological
Regulation |
Increase | Maximum relaxation | ||||
In-vivo Model | Male New Zealand white rabbits (3 to 3.5kg) were used in this study. | |||||
Experimental
Result(s) |
The study demonstrated a synergistic interaction between the alpha-adrenergic blockade and the potentiation of the nitric oxide/cyclic guanosine monophosphate pathway to increase neurogenic relaxation of trabecular smooth muscle relaxation. |