Drug Combination Details
General Information of the Combination (ID: C82816) | |||||
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Name | Taxifolin NP Info | + | Sorafenib Drug Info | ||
Structure | + | ||||
Disease |
Hepatocellular carcinoma
[ICD-11: 2C12]
|
Investigative | [1] |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. Enhancing Drug Efficacy by This Combination | ||||||
Achieving Therapeutic Synergy | Click to Show/Hide | |||||
Experiment 1 Reporting the Effect of This Combination | [1] | |||||
Molecule(s)
Regulation |
Down-regulation | Expression | FOXP3 | Molecule Info |
Pathway MAP
|
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In-vitro Model | Hep-G2 | CVCL_0027 | Hepatocellular carcinoma | Homo sapiens | ||
Experimental
Result(s) |
Sor-Tau combination led to FOXP3 down-regulation in hepatic cancer cells (HepG2) and improved therapeutic efficacy of sorafenib treated HCC. |
References | ||||
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Reference 1 | Sorafenib- Taurine Combination Model for Hepatocellular Carcinoma Cells: Immunological Aspects. Asian Pac J Cancer Prev. 2019 Oct 1;20(10):3007-3013. |