Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
α. Decreasing Adverse Drug Reaction by This Combination |
Decreasing Adverse Drug Reaction |
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Experiment 1 Reporting the Effect of This Combination |
[1] |
In-vitro Model |
MC B6-1 cells dissociated from solid tumor |
Fibrosarcoma |
Rattus norvegicus |
In-vivo Model |
The MC B6-1 fibrosarcoma was originally induced by s.c.injection of 2 mg of methylcholanthrene in a female C57BL/6 mouse and serially transplanted in syngeneic mice. |
Experimental
Result(s) |
The addition of selenium decreases the nephrotoxicity of cis-DDP. |