Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
α. Enhancing Drug Efficacy by This Combination |
Achieving Therapeutic Synergy |
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Experiment 1 Reporting the Effect of This Combination |
[1] |
In-vitro Model |
HL-60 |
CVCL_0002
|
Adult acute myeloid leukemia |
Homo sapiens |
MOLT-3 |
CVCL_0624
|
Adult T acute lymphoblastic leukemia |
Homo sapiens |
L1210 |
CVCL_0382
|
Mouse leukemia |
Mus musculus |
In-vivo Model |
Male CD2F1 mice (24-28 g) were injested with L1210 leukemic cells intravenously into the lateral tail vein. |
Experimental
Result(s) |
The combined treatment produced a synergistic loss of clonogenicity in human myeloid (HL-60) and lymphoid (MOLT-3) leukemic cell lines. |