Drug Combination Details
| General Information of the Combination (ID: C95068) | |||||
|---|---|---|---|---|---|
| Name | N-butylphthalide NP Info | + | Fluconazole Drug Info | ||
| Structure |
|
+ |
|
||
| Disease |
Candidosis
[ICD-11: 1F23]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BICDL1 | Molecule Info | ||
| Down-regulation | Expression | BICDL2 | Molecule Info | |||
| Biological
Regulation |
Up-regulation | ROS accumulation | ||||
| In-vitro Model | Candida albicans | Microorganism model | Candida albicans | |||
| Experimental
Result(s) |
The synergistic effects between n-butylphthalide and fluconazole potentially relied on the mechanism that n-butylphthalide significantly promoted drug uptake, and suppressed drug efflux via down-regulating the drug transporter encoding genes CDR1 and CDR2. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Antifungal Activity and Potential Mechanism of N-Butylphthalide Alone and in Combination With Fluconazole Against Candida albicans. Front Microbiol. 2019 Jul 2;10:1461. | |||
