Drug Combination Details
General Information of the Combination (ID: C95122) | |||||
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Name | Cidofovir NP Info | + | Cetuximab Drug Info | ||
Structure | + | ||||
Disease |
Cervical cancer
[ICD-11: 2C77]
|
Investigative | [1] |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. Enhancing Drug Efficacy by This Combination | ||||||
Achieving Therapeutic Synergy | Click to Show/Hide | |||||
Experiment 1 Reporting the Effect of This Combination | [1] | |||||
Molecule(s)
Regulation |
Up-regulation | Phosphorylation | H2AFX | Molecule Info |
Pathway MAP
|
|
In-vitro Model | HeLa | CVCL_0030 | Endocervical adenocarcinoma | Homo sapiens | ||
ME-180 | CVCL_1401 | Cervical squamous cell carcinoma | Homo sapiens | |||
C-33 A | CVCL_1094 | Cervical squamous cell carcinoma | Homo sapiens | |||
In-vivo Model | For a xenograft model, cells (2*106 Me180, HeLa, or C33A) were injected subcutaneously into female nude mice aged 10-12weeks (Elevage Janvier). | |||||
Experimental
Result(s) |
Cidofovir and Cetuximab have synergistic antitumor effect in HPV-positive tumors. |