Drug Combination Details
General Information of the Combination (ID: C95441) | |||||
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Name | Vincristine NP Info | + | Methotrexate Drug Info | ||
Structure | + | ||||
Disease |
Acute lymphoblastic leukemia
[ICD-11: 2B33]
|
Investigative | [1] |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. Enhancing Drug Efficacy by This Combination | ||||||
Achieving Therapeutic Synergy | Click to Show/Hide | |||||
Experiment 1 Reporting the Effect of This Combination | [1] | |||||
In-vitro Model | MOLT-3 | CVCL_0624 | Adult T acute lymphoblastic leukemia | Homo sapiens | ||
Experimental
Result(s) |
Simultaneous exposure of VCR and MTX produced subadditive or mutually protective interactions. |
References | ||||
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Reference 1 | Effects of vincristine in combination with methotrexate and other antitumor agents in human acute lymphoblastic leukemia cells in culture. Cancer Res. 1988 Jan 15;48(2):351-6. |