Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
α. Enhancing Drug Efficacy by This Combination |
Achieving Therapeutic Synergy |
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Experiment 1 Reporting the Effect of This Combination |
[1] |
In-vitro Model |
MIA PaCa-2 |
CVCL_0428
|
Pancreatic ductal adenocarcinoma |
Homo sapiens |
PANC-1 |
CVCL_0480
|
Pancreatic ductal adenocarcinoma |
Homo sapiens |
Experimental
Result(s) |
GLA has a synergistic effect with gemcitabine at concentrations that correspond to in vivo therapeutic doses. GLA with 5-FU is synergistic only at a tight range of high concentrations of 5-FU. GLA lacks toxic side effects and may be useful in combination with gemcitabine. |