Drug Details
General Information of the Drug (ID: DR0683) | ||||
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Name |
Thioridazine
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Synonyms |
Aldazine; Mallorol; Malloryl; Meleril; Mellaril; Mellarit; Mellerets; Mellerette; Melleretten; Melleril; Melleryl; Metlaril; Novoridazine; Orsanil; Ridazine; Sonapax; Stalleril; Thioridazin; Thioridazinum; Thioxidazine; Tioridazin; Tioridazina; Thioridazine Hcl; Thioridazine Hcl Intensol; Thioridazine prolongatum; Thoridazine hydrochloride; Dl-Thioridazine; Mellaril (TN); Mellaril-S; Melleril (liquid); Novoridazine (TN); TP-21; Thioridazine, prolongatum; Thioridazinum [INN-Latin]; Thioril (TN); Tioridazina [INN-Spanish]; Mellaril-S (TN); Thioridazine (USP/INN); Thioridazine [USAN:INN:BAN]; Mellaril (*Hydrochloride*); (+-)-Thioridazine; 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine; 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulfanyl-phenothiazine; 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine; 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylthio)-10H-phenothiazine; 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine; 2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazine; 3-Methylmercapto-N-(2'-(N-methyl-2-piperidyl)ethyl)phenothiazine
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Molecular Type |
Small molecule
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Disease | Schizophrenia [ICD-11: 6A20] | Approved | [1] | |
Structure |
Click to Download Mol2D MOL |
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Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | ||||
Formula |
C21H26N2S2
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PubChem CID | ||||
Canonical SMILES |
CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC
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InChI |
1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
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InChIKey |
KLBQZWRITKRQQV-UHFFFAOYSA-N
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CAS Number |
CAS 50-52-2
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ChEBI ID | ||||
TTD Drug ID | ||||
DrugBank ID |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
Curcumin | Hellenia speciosa | Click to Show/Hide the Molecular Data of This NP | ||||
Augmenting Drug Sensitivity | Click to Show/Hide | |||||
Representative Experiment Reporting the Effect of This Combination | [2] | |||||
Detail(s) | Combination Info click to show the detail info of this combination | |||||
Molecule(s)
Regulation |
Down-regulation | Expression | CFLAR | Molecule Info |
Pathway MAP
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Up-regulation | Expression | GABPA | Molecule Info | |||
Down-regulation | Expression | MCL1 | Molecule Info |
Pathway MAP
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Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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Up-regulation | Expression | PSMA5 | Molecule Info |
Pathway MAP
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Biological
Regulation |
Induction | ROS generation | ||||
In-vitro Model | AMC-HN-4 | CVCL_5962 | Tongue squamous cell carcinoma | Homo sapiens | ||
Experimental
Result(s) |
Thioridazine plus curcumin induces proteasome activity by up-regulating PSMA5 expression via NOX4-mediated ROS production and that down-regulation of c-FLIP and Mcl-1 expression post-translationally is involved in apoptosis. |
Target and Pathway | ||||
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Target(s) | Dopamine D2 receptor (D2R) | Molecule Info | [3] | |
KEGG Pathway | Rap1 signaling pathway | Click to Show/Hide | ||
2 | cAMP signaling pathway | |||
3 | Neuroactive ligand-receptor interaction | |||
4 | Gap junction | |||
5 | Dopaminergic synapse | |||
6 | Parkinson's disease | |||
7 | Cocaine addiction | |||
8 | Alcoholism | |||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | Click to Show/Hide | ||
2 | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||
3 | Dopamine receptor mediated signaling pathway | |||
4 | Nicotine pharmacodynamics pathway | |||
Reactome | Dopamine receptors | Click to Show/Hide | ||
2 | G alpha (i) signalling events | |||
WikiPathways | Hypothetical Network for Drug Addiction | Click to Show/Hide | ||
2 | Monoamine GPCRs | |||
3 | GPCRs, Class A Rhodopsin-like | |||
4 | Genes and (Common) Pathways Underlying Drug Addiction | |||
5 | GPCR ligand binding | |||
6 | GPCR downstream signaling | |||
7 | Nicotine Activity on Dopaminergic Neurons |