Drug Details
General Information of the Drug (ID: DR1575) | ||||
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Name |
Letrozole
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Synonyms |
Femara; Femera; Letoval; Letrozol; Novartis Brand of Letrozole; CGS 20267; CGS-20267; FEM-345; Femara (TN); Letrozole [USAN:INN]; CGS 20267, Femara, Piroxicam, Letrozole; Letrozole (JAN/USP/INN); 1-[Bis-(4-cyanophenyl)methyl]-1,2,4-triazole; 1-[bis(4-cyanophenyl)methyl]-1,2,4-triazole; 4,4'-((1h-1,2,4-triazol-1-yl)methylene)dibenzonitrile; 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile; 4,4'-(1H-1,2,4-triazol-1-yl-methylene)-bis(benzonitrile); 4,4'-(1H-1,2,4-triazol-1-ylmethanediyl)dibenzonitrile; 4,4'-(1H-1,2,4-triazol-1-ylmethylene)bis-Benzonitrile Letrozole; 4,4'-(1h-1,2,4-triazol-1-ylmethylene) bis-benzonitrile; 4,4'-(1h-1,2,4-triazol-1-ylmethylene)bis-benzonitrile; 4,4'-(1h-1,2,4-triazol-1-ylmethylene)bisbenzonitrile; 4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile
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Molecular Type |
Small molecule
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Disease | Breast cancer [ICD-11: 2C60] | Approved | [1] | |
Structure |
Click to Download Mol2D MOL |
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Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | ||||
Formula |
C17H11N5
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PubChem CID | ||||
Canonical SMILES |
C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3
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InChI |
1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
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InChIKey |
HPJKCIUCZWXJDR-UHFFFAOYSA-N
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CAS Number |
CAS 112809-51-5
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ChEBI ID | ||||
TTD Drug ID | ||||
DrugBank ID |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
Curcumin | Hellenia speciosa | Click to Show/Hide the Molecular Data of This NP | ||||
Augmenting Drug Sensitivity | Click to Show/Hide | |||||
Representative Experiment Reporting the Effect of This Combination | [2] | |||||
Detail(s) | Combination Info click to show the detail info of this combination | |||||
Molecule(s)
Regulation |
Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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In-vivo Model | RL-952 cells at logarithmic growth phase were suspended to a density of 5*107/mL and subcutaneously injected into ovariectomized nude mice through the dorsal skin of each side (0.1 mL/mouse, containing 5*106 cells). | |||||
Experimental
Result(s) |
Treatment with either letrozole or curcumin could inhibit the xenografted endometrial tumor growth via inducing apoptosis in tumor cells. Combination of letrozole and curcumin further strengthened the inhibitory effect on tumor growth. | |||||
Testosterone | Homo sapiens | Click to Show/Hide the Molecular Data of This NP | ||||
Achieving Therapeutic Synergy | Click to Show/Hide | |||||
Representative Experiment Reporting the Effect of This Combination | [3] | |||||
Detail(s) | Combination Info click to show the detail info of this combination | |||||
In-vivo Model | A total of 48 adult (8 weeks old) male Sprague-Dawley rats with mean weight of 250-300 gr were enrolled in this study. | |||||
Experimental
Result(s) |
Both testosterone and its combination with letrozole increased lumbar and femoral BMD of orchiectomized rats, with a higher increase in lumbar BMD in O + T group. |
Target and Pathway | ||||
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Target(s) | Aromatase (CYP19A1) | Molecule Info | [4] | |
BioCyc | Superpathway of steroid hormone biosynthesis | Click to Show/Hide | ||
2 | Estradiol biosynthesis II | |||
3 | Estradiol biosynthesis I | |||
KEGG Pathway | Steroid hormone biosynthesis | Click to Show/Hide | ||
2 | Metabolic pathways | |||
3 | Ovarian steroidogenesis | |||
NetPath Pathway | FSH Signaling Pathway | Click to Show/Hide | ||
Panther Pathway | Androgen/estrogene/progesterone biosynthesis | Click to Show/Hide | ||
Pathwhiz Pathway | Androgen and Estrogen Metabolism | Click to Show/Hide | ||
Reactome | Endogenous sterols | Click to Show/Hide | ||
WikiPathways | Metapathway biotransformation | Click to Show/Hide | ||
2 | Tryptophan metabolism | |||
3 | Oxidation by Cytochrome P450 | |||
4 | Ovarian Infertility Genes | |||
5 | Metabolism of steroid hormones and vitamin D | |||
6 | FSH signaling pathway | |||
7 | Integrated Breast Cancer Pathway | |||
8 | Phase 1 - Functionalization of compounds |