Drug Details
General Information of the Drug (ID: DR5094) | ||||
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Name |
Methylene blue
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Synonyms |
methylene blue; 61-73-4; Basic blue 9; Methylthioninium chloride; Swiss Blue; Solvent blue 8; Chromosmon; 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride; Methylene Blue N; Methylene Blue BB; Methylene Blue anhydrous; Bleu de methylene; Methylene Blue chloride; External Blue 1; Methylene Blue A; Methylene Blue B; Methylene Blue D; Methylene Blue G; C.I. Basic Blue 9; Calcozine Blue ZF; Methylene Blue BD; Methylene Blue BP; Methylene Blue BX; Methylene Blue BZ; Methylene Blue FZ; Methylene Blue GZ; Methylene Blue NZ; Methylene Blue SG; Methylene Blue SP; Methylene Blue ZF; Methylene Blue ZX; Tetramethylene Blue; Methylene Blue 2B; Methylenium ceruleum; Methylene Blue BBA; Methylene Blue BPC; Methylene Blue HGG; Methylene Blue IAD; Methylene Blue JFA; Sandocryl Blue BRL; Methylenblau; Methylene Blue 2BF; Methylene Blue 2BN; Methylene Blue 2BP; M-B Tabs; Rember; Mitsui Methylene Blue; Methylthionium chloride; Leather Pure Blue HB; Methylthionine chloride; Modr methylenova; Schultz No. 1038; Aizen Methylene Blue BH; Aizen Methylene Blue FZ; Methylene Blue polychrome; Methylene Blue Zinc Free; Yamamoto Methylene Blue B; D And C Blue Number 1; Tetramethylthionine chloride; Methylene Blue (Medicinal); Yamamoto Methylene Blue ZF; Ext D and C Blue No. 1; Methylene Blue I (Medicinal); Cloruro de metiltioninio; Methylene Blue NF (Medicinal); Methylthioninii chloridum; Hidaco Methylene Blue Salt Free; Methylene Blue BB (Zinc Free); Methylene Blue USP (Medicinal); Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride; Chlorure de methylthioninium; Methylene Blue USP XII (Medicinal); UNII-8NAP7826UB; Methylene Blue Chloride (Biological stain); C.I. 52015; X 138; 3,7-Bis(dimethylamino)phenazathionium chloride; MFCD00012111; 8NAP7826UB; CHEBI:6872; Urolene blue; Methylene Blue (C.I. 52015); CI 52015; azul de metileno; Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride (1:1); DSSTox_CID_3296; N-[7-(dimethylamino)-3H-phenothiazin-3-ylidene]-N-methylmethanaminium chloride; Ceruleum methylenum; DSSTox_RID_76963; DSSTox_GSID_23296; 12262-49-6; Methylenum coeruleum; CI-52015; CI Basic Blue 9; Caswell No. 567; Methylenblau [German]; Methylthionini chloridum; 3H-Phenothiazine, 3-methochloride; Modr Methylenova [Czech]; CHEMBL405110; Modr zasadita 9; Modr Zasadita 9 [Czech]; CAS-61-73-4; N-(7-(dimethylamino)-3H-phenothiazin-3-ylidene)-N-methylmethanaminium chloride; NSC3089; CCRIS 833; Metiltioninio cloruro [DCIT]; Metiltioninio cloruro; Modr Rozpoustedlova 8 [Czech]; 3H-Phenothiazine, 7-(dimethylamino)-3-(methylimino)-, 3-methochloride; Modr rozpoustedlova 8; NSC215213; NSC617593; C.I. 52 015; HSDB 1405; Methylene Blue, pure, certified, residual water; NSC-215213; NSC-617593; NCGC00167496-01; NCGC00167496-03; Phenothiazin-5-ium,7-bis(dimethylamino)-, chloride; EINECS 200-515-2; Methylthioninii chloridum [INN-Latin]; EPA Pesticide Chemical Code 039505; NSC 215213; Cloruro de metiltioninio [INN-Spanish]; WLN: T C666 BS EY INJ EUK1&1 MN1&1 &G &421; Provayblue; Chlorure de methylthioninium [INN-French]; [7-(dimethylamino)phenothiazin-3-ylidene]dimethylamine, chloride; Lowacryl blue 9; Methylene Azure II; Prestwick_326; Ehrlichs reagent III; Loefflers Methylene Blue; Methylene Blue (Inhibitor); SCHEMBL1351; MLS000719838; DOG (COUCH) GRASS Powder; DTXSID0023296; Methylthioninium chloride [INN]; C.I. Basic Blue 9 (8CI); HMS2598O03; Pharmakon1600-01505444; CI NO 52015; NSC-3089; Tox21_112497; Tox21_302087; NSC759135; s4535; SBB060907; STK018918; AKOS000486124; AKOS015916406; Tox21_112497_1; CCG-267696; DB09241; MCULE-7744087830; NSC-759135; 4-(1-HYDROXY-ETHYL)-BENZOICACID; NCGC00255351-01; 105504-42-5; AC-15225; AK326199; AS-35256; Basic Blue 9;Tetramethylthionine chloride; HY-14536; Methylene Blue, 1% w/v aqueous solution; SMR000304367; ST093058; SY076497; Methylthioninium Chloride (Methylene Blue); Methylene Blue (C.I. 52015) BioChemica; A0574; FT-0622580; M0501; ST50406802; C00220; 3,7-Bis(dimethylamino)-5-phenothiazinium Chloride; Q422134; 3,7-bis(dimethylamino)-phenothiazin-5-ium chloride salt; [7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride; [7-(dimethylamino)dibenzo[b,e]1,4-thiazin-3-yl]dimethylamine, chloride; 3-N,3-N,7-N,7-N-tetramethylphenothiazin-5-ium-3,7-diamine;chloride; 1341-90-8; 152071-32-4; 6476-03-5; 97130-83-1
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Molecular Type |
Small molecule
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Disease | Acquired methaemoglobinaemia [ICD-11: 3A93] | Approved | [1] | |
Structure |
Click to Download Mol2D MOL |
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Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | ||||
Formula |
C16H18ClN3S
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PubChem CID | ||||
Canonical SMILES |
CN(C)C1=CC2=C(C=C1)N=C3C=CC(=[N+](C)C)C=C3S2.[Cl-]
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InChI |
1S/C16H18N3S.ClH/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;/h5-10H,1-4H3;1H/q+1;/p-1
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InChIKey |
CXKWCBBOMKCUKX-UHFFFAOYSA-M
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CAS Number |
CAS 61-73-4
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ChEBI ID | ||||
TTD Drug ID | ||||
DrugBank ID |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
Salicylic acid | Salix abscondita | Click to Show/Hide the Molecular Data of This NP | ||||
Achieving Therapeutic Synergy | Click to Show/Hide | |||||
Representative Experiment Reporting the Effect of This Combination | [2] | |||||
Detail(s) | Combination Info click to show the detail info of this combination | |||||
In-vitro Model | MDA-MB-231 | CVCL_0062 | Breast adenocarcinoma | Homo sapiens | ||
Experimental
Result(s) |
Cancer cell killing efficiency of MB increases in the combination with SA due to reduction prevention and stabilization of monomeric form of MB. |
Target and Pathway | ||||
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Target(s) | Guanylate cyclase (GC) | Molecule Info | [3] | |
Monoamine oxidase (MAO) | Molecule Info | [4] |