Drug Details
General Information of the Drug (ID: DR5670) | ||||
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Name |
Ibuprofen
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Synonyms |
ibuprofen; 15687-27-1; 2-(4-Isobutylphenyl)propanoic acid; Motrin; Brufen; Advil; Nurofen; Dolgit; Nuprin; Liptan; Ibuprocin; Buburone; Medipren; Butylenin; Ibumetin; Anflagen; Lamidon; Ebufac; Mynosedin; Trendar; Roidenin; Apsifen; Haltran; Epobron; Nobgen; Adran; Nobfen; Rufen; PediaProfen; Andran; Bluton; Nobfelon; Pantrop; Brufort; Suspren; Rebugen; Tabalon; Inabrin; (RS)-Ibuprofen; Urem; Anco; 2-[4-(2-methylpropyl)phenyl]propanoic acid; Ibu-slo; Napacetin; Brufanic; Ibuprohm; Ibufen; Ibren; 4-Isobutylhydratropic acid; p-Isobutylhydratropic acid; Actiprofen; Alaxan; Algofen; Amelior; Amersol; Amibufen; Anafen; Antagil; Antalfene; Antarene; Antiflam; Artofen; Artril; Balkaprofen; Betaprofen; Bloom; Brofen; Bruflam; Bufeno; Bufigen; Bukrefen; Bupron; Buracaps; Burana; Carol; Cesra; Citalgan; Cobo; Codral; Combiflam; Cunil; Daiprophen; Dalsy; Dansida; Dentigoa; Dibufen; Dignoflex; Dolgirid; Dolibu; Dolmaral; Dolocyl; Dolofen; Dolofin; Dolofort; Dologel; Dolomax; Doloren; Dolormin; Doltibil; Dolven; Dorival; Drin; Duafen; Duobrus; Dysdolen; Easifon; Emflam; Eputex; Ergix; Esprenit; Exneural; Faspic; Femadon; Femafen; Femapirin; Femidol; Fenbid; Fendol; Fenspan; Fibraflex; Gelufene; Gofen; Grefen; Gynofug; Ibol; Ibu; Ibubest; Ibubeta; Ibucasen; Ibudol; Ibudolor; Ibuflamar; Ibufug; Ibugel; Ibugen; Ibugesic; Ibuhexal; Ibulagic; Ibular; Ibulav; Ibuleve; Ibulgan; Ibumed; Ibumerck; Ibupirac; Ibuprin; Ibuprofene; Ibuprofeno; Ibuprofenum; Ibuprophen; Ibusal; Ibutid; Ifen; Inflam; Inoven; Ipren; Irfen; Isodol; Jenaprofen; Junifen; Kesan; Kratalgin; Lebrufen; Librofem; Lidifen; Lopane; Malafene; Manypren; Melfen; Mensoton; Midol; Moment; Narfen; Neobrufen; Nerofen; Noalgil; Nobafon; Noritis; Norton; Novadol; Novogent; Novoprofen; Nuprilan; Optifen; Opturem; Oralfene; Ostarin; Ostofen; Ozonol; Paduden; Panafen; Paxofen; Perofen; Proartinal; Profen; Proflex; Provon; Quadrax; Rafen; Ranofen; Relcofen; Rhinadvil; Rofen; Rufin; Rupan; Sadefen; Salivia; Salprofen; Seclodin; Sednafen; Seklodin; Seskafen; Siyafen; Solpaflex; Solufen; Stelar; Sugafen; Suprafen; Syntofene; Tatanal; Tempil; Tofen; Tonal; Unipron; Upfen; Uprofen; Zafen; Zofen; DOLO PUREN; Deep Relief; Donjust B; Motrin IB; Novogent N; Togal N; Adex 200; Artril 300; Brufen 400; I 4883; IP 82; IP82; Midol 200; RD 13621; Tabalon 400; U 18573; UCB 79171; VUFB 9649; Act-3; Advil (TN); Ak+C2278tren; Aktre (TN); Alaxan (TN); Algoflex (TN); Alivium (TN); Am-Fam 400; Apsifen-F; Arthrofen (TN); Bonifen (TN); Brufen (TN); Bugesic (TN); Burana (TN); Caldolor (TN); Calprofen (TN); Cap-Profen; Dalsy (TN); Dismenol (TN); Diverin (TN); Dolgit (TN); Dolo-Dolgit; Dolofen-F; Dolofort (TN); Doloraz (TN); Dolormin (TN); Dorival (TN); Dura-Ibu; Ebufac (TN); Emflam-200; EmuProfen (TN); Espidifen (TN); Eve (TN); Fenbid (TN); Fenpaed (TN); Finalflex (TN); Galprofen (TN); Hedex (TN); Herron Blue (TN); IB-100; IBUFEN (TN); IP-82; Ibalgin (TN); Ibu-Attritin; Ibu-Tab; Ibu-Tab 200; Ibu-slow; IbuHEXAL (TN); Ibugel (TN); Ibuleve (TN); Ibum (TN); Ibumax (TN); Ibumetin (TN); Ibuprom (TN); Ibuprosyn (TN); Ibux (TN); Ibuxin (TN); Ipren (TN); Kratalgin (TN); Medicol (TN); Moment (TN); Motrin (TN); Nagifen-D; Narfen (TN); Neo-Helvagit; Neo-Mindol; Neobrufen (TN); Neofen (TN); Norvectan (TN); Novo-Profen; Nuprin (TN); Nureflex (TN); Nurofen (TN); Orbifen (TN); Panafen (TN); Pedia-Profen; Perifar (TN); Profin (TN); Ratiodolor (TN); Retard (TN); Rimafen (TN); Salvarina (TN); Solpaflex (TN); Spedifen (TN); Speedpain NANO (TN); Spidifen (TN); Tab-Profen; U-18573; Upfen (TN); ACHES-N-PAIN; Act-3 (TN); Dolo-Spedifen (TN); I-profen (TN); IBU-Ratiopharm (TN); Ibu-Vivimed (TN); U-18,573; IBUPROPHEN
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Molecular Type |
Small molecule
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Disease | Pain [ICD-11: MG30-MG3Z] | Approved | [1] | |
Structure |
Click to Download Mol2D MOL |
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Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | ||||
Formula |
C13H18O2
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PubChem CID | ||||
Canonical SMILES |
CC(C)CC1=CC=C(C=C1)C(C)C(=O)O
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InChI |
1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
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InChIKey |
HEFNNWSXXWATRW-UHFFFAOYSA-N
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CAS Number |
CAS 15687-27-1
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ChEBI ID | ||||
TTD Drug ID | ||||
DrugBank ID |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
1-deoxynojirimycin | Commelina communis | Click to Show/Hide the Molecular Data of This NP | ||||
Achieving Therapeutic Synergy | Click to Show/Hide | |||||
Representative Experiment Reporting the Effect of This Combination | [2] | |||||
Detail(s) | Combination Info click to show the detail info of this combination | |||||
In-vivo Model | Animal models of Parkinson's disease (PD) were used in this study. | |||||
Experimental
Result(s) |
MPTP induced death of dopaminergic neurons, microgliosis, increase of gliapses, motor impairment and neuroinflammation in mice, which were inhibited by combined 1-deoxynojirimycin and ibuprofen treatment. | |||||
Epigallocatechin gallate | Hamamelis virginiana | Click to Show/Hide the Molecular Data of This NP | ||||
Achieving Therapeutic Synergy | Click to Show/Hide | |||||
Representative Experiment Reporting the Effect of This Combination | [3] | |||||
Detail(s) | Combination Info click to show the detail info of this combination | |||||
Molecule(s)
Regulation |
Up-regulation | Cleavage | CASP9 | Molecule Info |
Pathway MAP
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Up-regulation | Expression | TP53 | Molecule Info |
Pathway MAP
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In-vitro Model | DU145 | CVCL_0105 | Prostate carcinoma | Homo sapiens | ||
Experimental
Result(s) |
EGCG+ibuprofen treatment has a synergistic effect on apoptosis, and xidative stress, directly or indirectly via ceramide synthesis mediated pro-apoptotic signaling. |
Target and Pathway | ||||
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Target(s) | C-X-C chemokine receptor 1 (CXCR1) | Molecule Info | [4] | |
C-X-C chemokine receptor 2 (CXCR2) | Molecule Info | [4] | ||
Interleukin-8 (IL8) | Molecule Info | [5] | ||
Prostaglandin G/H synthase 2 (COX-2) | Molecule Info | [6] | ||
BioCyc | Aspirin-triggered lipoxin biosynthesis | Click to Show/Hide | ||
2 | Aspirin triggered resolvin D biosynthesis | |||
3 | C20 prostanoid biosynthesis | |||
4 | Aspirin triggered resolvin E biosynthesis | |||
KEGG Pathway | Arachidonic acid metabolism | Click to Show/Hide | ||
2 | Metabolic pathways | |||
3 | NF-kappa B signaling pathway | |||
4 | VEGF signaling pathway | |||
5 | TNF signaling pathway | |||
6 | Retrograde endocannabinoid signaling | |||
7 | Serotonergic synapse | |||
8 | Ovarian steroidogenesis | |||
9 | Oxytocin signaling pathway | |||
10 | Regulation of lipolysis in adipocytes | |||
11 | Leishmaniasis | |||
12 | Pathways in cancer | |||
13 | Chemical carcinogenesis | |||
14 | MicroRNAs in cancer | |||
15 | Small cell lung cancer | |||
16 | Cytokine-cytokine receptor interaction | |||
17 | Chemokine signaling pathway | |||
18 | Endocytosis | |||
19 | Epithelial cell signaling in Helicobacter pylori infection | |||
20 | Toll-like receptor signaling pathway | |||
21 | NOD-like receptor signaling pathway | |||
22 | RIG-I-like receptor signaling pathway | |||
23 | Non-alcoholic fatty liver disease (NAFLD) | |||
24 | Shigellosis | |||
25 | Salmonella infection | |||
26 | Pertussis | |||
27 | Legionellosis | |||
28 | Chagas disease (American trypanosomiasis) | |||
29 | Malaria | |||
30 | Amoebiasis | |||
31 | Hepatitis C | |||
32 | Hepatitis B | |||
33 | Influenza A | |||
34 | Transcriptional misregulation in cancer | |||
35 | Bladder cancer | |||
36 | Rheumatoid arthritis | |||
NetPath Pathway | IL1 Signaling Pathway | Click to Show/Hide | ||
2 | TSH Signaling Pathway | |||
3 | IL4 Signaling Pathway | |||
4 | TGF_beta_Receptor Signaling Pathway | |||
5 | IL5 Signaling Pathway | |||
6 | IL2 Signaling Pathway | |||
7 | TNFalpha Signaling Pathway | |||
8 | IL-7 Signaling Pathway | |||
9 | IL3 Signaling Pathway | |||
10 | TSLP Signaling Pathway | |||
11 | TCR Signaling Pathway | |||
Panther Pathway | Endothelin signaling pathway | Click to Show/Hide | ||
2 | Inflammation mediated by chemokine and cytokine signaling pathway | |||
3 | Toll receptor signaling pathway | |||
4 | CCKR signaling map ST | |||
5 | Interleukin signaling pathway | |||
Pathwhiz Pathway | Arachidonic Acid Metabolism | Click to Show/Hide | ||
Pathway Interaction Database | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | Click to Show/Hide | ||
2 | S1P1 pathway | |||
3 | C-MYB transcription factor network | |||
4 | Signaling mediated by p38-alpha and p38-beta | |||
5 | Calcium signaling in the CD4+ TCR pathway | |||
6 | IL8- and CXCR1-mediated signaling events | |||
7 | IL8- and CXCR2-mediated signaling events | |||
8 | LPA receptor mediated events | |||
9 | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | |||
10 | Glucocorticoid receptor regulatory network | |||
11 | ATF-2 transcription factor network | |||
12 | IL8-mediated signaling events | |||
13 | AP-1 transcription factor network | |||
14 | Regulation of nuclear beta catenin signaling and target gene transcription | |||
15 | Syndecan-2-mediated signaling events | |||
16 | Syndecan-3-mediated signaling events | |||
Reactome | Chemokine receptors bind chemokines | Click to Show/Hide | ||
2 | G alpha (i) signalling events | |||
3 | Senescence-Associated Secretory Phenotype (SASP) | |||
4 | Peptide ligand-binding receptors | |||
5 | ATF4 activates genes | |||
WikiPathways | Prostaglandin Synthesis and Regulation | Click to Show/Hide | ||
2 | Arachidonic acid metabolism | |||
3 | Aryl Hydrocarbon Receptor | |||
4 | Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis | |||
5 | Spinal Cord Injury | |||
6 | Integrated Pancreatic Cancer Pathway | |||
7 | Eicosanoid Synthesis | |||
8 | Selenium Micronutrient Network | |||
9 | GPCRs, Class A Rhodopsin-like | |||
10 | Differentiation Pathway | |||
11 | Peptide GPCRs | |||
12 | GPCR ligand binding | |||
13 | GPCR downstream signaling | |||
14 | GPCRs, Other | |||
15 | Toll-like receptor signaling pathway | |||
16 | SIDS Susceptibility Pathways | |||
17 | Senescence and Autophagy in Cancer | |||
18 | IL-3 Signaling Pathway | |||
19 | Bladder Cancer | |||
20 | Activation of Genes by ATF4 | |||
21 | EBV LMP1 signaling | |||
22 | Corticotropin-releasing hormone | |||
23 | Allograft Rejection | |||
24 | TSLP Signaling Pathway | |||
25 | Regulation of toll-like receptor signaling pathway |