Drug Details
General Information of the Drug (ID: DR5673) | ||||
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Name |
Nanoliposomal C6-ceramide
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Disease | Hepatocellular carcinoma [ICD-11: 2C12] | Investigative | [1] |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
Vinblastine | Catharanthus roseus | Click to Show/Hide the Molecular Data of This NP | ||||
Achieving Therapeutic Synergy | Click to Show/Hide | |||||
Representative Experiment Reporting the Effect of This Combination | [1] | |||||
Detail(s) | Combination Info click to show the detail info of this combination | |||||
Molecule(s)
Regulation |
Up-regulation | Expression | MAP1LC3A | Molecule Info |
Pathway MAP
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In-vitro Model | LS174T | CVCL_1384 | Colon adenocarcinoma | Homo sapiens | ||
Hep-G2 | CVCL_0027 | Hepatocellular carcinoma | Homo sapiens | |||
In-vivo Model | Tumor cells were inoculated into the left flank of 7 week-old female athymic nude mice by subcutaneous injection of 6 * 106 LS174T cells in 0.1 mL Hanks Balanced Salt Solution. | |||||
Experimental
Result(s) |
In vitro and in vivo data support a synergistic antitumor activity of the nanoliposomal C6-ceramide and vinblastine combination, potentially mediated by an autophagy mechanism. |
Target and Pathway | ||||
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Target(s) | T-cell surface glycoprotein CD4 (CD4) | Molecule Info | [2] | |
KEGG Pathway | Cell adhesion molecules (CAMs) | Click to Show/Hide | ||
2 | Antigen processing and presentation | |||
3 | Hematopoietic cell lineage | |||
4 | T cell receptor signaling pathway | |||
5 | Primary immunodeficiency | |||
NetPath Pathway | Leptin Signaling Pathway | Click to Show/Hide | ||
Pathway Interaction Database | TCR signaling in naï | Click to Show/Hide | ||
2 | ||||
3 | IL12-mediated signaling events | |||
4 | CXCR4-mediated signaling events | |||
5 | C-MYB transcription factor network | |||
6 | IL23-mediated signaling events | |||
7 | Arf1 pathway | |||
8 | Notch-mediated HES/HEY network | |||
9 | IL12 signaling mediated by STAT4 | |||
Reactome | Binding and entry of HIV virion | Click to Show/Hide | ||
2 | Phosphorylation of CD3 and TCR zeta chains | |||
3 | Translocation of ZAP-70 to Immunological synapse | |||
4 | Generation of second messenger molecules | |||
5 | PD-1 signaling | |||
WikiPathways | TCR Signaling Pathway | Click to Show/Hide | ||
2 | Cytokines and Inflammatory Response | |||
3 | Host Interactions of HIV factors | |||
4 | Defensins | |||
5 | HIV Life Cycle | |||
6 | TCR signaling | |||
7 | Costimulation by the CD28 family |