Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug |
Amentoflavone |
Gingko biloba
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Achieving Therapeutic Synergy |
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Representative Experiment Reporting the Effect of This Combination |
[2] |
Detail(s) |
Combination Info
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In-vitro Model |
Enterococcus faecium ATCC 19434 |
Microorganism model |
Enterococcus faecium |
Staphylococcus aureus ATCC 25923 |
Microorganism model |
Staphylococcus aureus |
Streptococcus mutans ATCC 3065 |
Microorganism model |
Streptococcus mutans |
Escherichia coli ATCC 43895 |
Microorganism model |
Escherichia coli |
Escherichia coli ATCC 25922 |
Microorganism model |
Escherichia coli |
Pseudomonas aeruginosa ATCC 27853 |
Microorganism model |
Pseudomonas aeruginosa |
Experimental
Result(s) |
Amentoflavone had a considerable antibacterial effect and synergistic interaction with antibiotics against various bacterial strains. The formation of hydroxyl radical would be a cause of the synergistic effect and that this oxidative stress originated from a transient NADH depletion. . |