Natural Product (NP) Details
General Information of the NP (ID: NP0904) | |||||
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Name |
Ginsenoside
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Species Origin | Panax ginseng ... | Click to Show/Hide | |||
Panax ginseng | |||||
Disease | Lung cancer [ICD-11: 2C25] | Phase 2 | [1] | ||
Herb ID | |||||
SymMap ID |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
Reorafenib | Colorectal cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
Achieving Therapeutic Synergy | Click to Show/Hide | |||||
Representative Experiment Reporting the Effect of This Combination | [2] | |||||
Detail(s) | Combination Info click to show the detail info of this combination | |||||
Molecule(s)
Regulation |
Down-regulation | Expression | BIRC5 | Molecule Info |
Pathway MAP
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Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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In-vitro Model | Hep-G2 | CVCL_0027 | Hepatocellular carcinoma | Homo sapiens | ||
Experimental
Result(s) |
The synergistic inhibitory effect presented by the combination therapy was dependent on the gradient concentration and treatment time. | |||||
Cyclophosphamide | Solid tumour/cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
Achieving Therapeutic Synergy | Click to Show/Hide | |||||
Representative Experiment Reporting the Effect of This Combination | [3] | |||||
Detail(s) | Combination Info click to show the detail info of this combination | |||||
In-vivo Model | C57BL/6 mice were inoculated by subcutaneous injection in the right front axilla with 1 * 106 Lewis cells. | |||||
Experimental
Result(s) |
Combination of Ginsenoside H dripping pills and cyclophosphamide improve paraneoplastic syndrome and inhibit postoperative recurrence via the reversion of Th1/Th2 shift. |
Target and Pathway | ||||
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Target(s) | Protein kinase C beta (PRKCB) | Molecule Info | [4] | |
KEGG Pathway | MAPK signaling pathway | Click to Show/Hide | ||
2 | ErbB signaling pathway | |||
3 | Ras signaling pathway | |||
4 | Rap1 signaling pathway | |||
5 | Calcium signaling pathway | |||
6 | Chemokine signaling pathway | |||
7 | NF-kappa B signaling pathway | |||
8 | HIF-1 signaling pathway | |||
9 | Phosphatidylinositol signaling system | |||
10 | Sphingolipid signaling pathway | |||
11 | mTOR signaling pathway | |||
12 | Vascular smooth muscle contraction | |||
13 | Wnt signaling pathway | |||
14 | VEGF signaling pathway | |||
15 | Focal adhesion | |||
16 | Tight junction | |||
17 | Gap junction | |||
18 | Natural killer cell mediated cytotoxicity | |||
19 | B cell receptor signaling pathway | |||
20 | Fc epsilon RI signaling pathway | |||
21 | Fc gamma R-mediated phagocytosis | |||
22 | Leukocyte transendothelial migration | |||
23 | Circadian entrainment | |||
24 | Long-term potentiation | |||
25 | Retrograde endocannabinoid signaling | |||
26 | Glutamatergic synapse | |||
27 | Cholinergic synapse | |||
28 | Serotonergic synapse | |||
29 | GABAergic synapse | |||
30 | Dopaminergic synapse | |||
31 | Long-term depression | |||
32 | Inflammatory mediator regulation of TRP channels | |||
33 | Insulin secretion | |||
34 | GnRH signaling pathway | |||
35 | Melanogenesis | |||
36 | Thyroid hormone synthesis | |||
37 | Thyroid hormone signaling pathway | |||
38 | Oxytocin signaling pathway | |||
39 | Aldosterone-regulated sodium reabsorption | |||
40 | Endocrine and other factor-regulated calcium reabsorption | |||
41 | Salivary secretion | |||
42 | Gastric acid secretion | |||
43 | Pancreatic secretion | |||
44 | Carbohydrate digestion and absorption | |||
45 | Amphetamine addiction | |||
46 | Morphine addiction | |||
47 | Vibrio cholerae infection | |||
48 | Leishmaniasis | |||
49 | African trypanosomiasis | |||
50 | Amoebiasis | |||
51 | Hepatitis B | |||
52 | Influenza A | |||
53 | Pathways in cancer | |||
54 | Proteoglycans in cancer | |||
55 | MicroRNAs in cancer | |||
56 | Glioma | |||
57 | Non-small cell lung cancer | |||
58 | Choline metabolism in cancer | |||
NetPath Pathway | IL2 Signaling Pathway | Click to Show/Hide | ||
Panther Pathway | Alzheimer disease-amyloid secretase pathway | Click to Show/Hide | ||
2 | Angiogenesis | |||
3 | Apoptosis signaling pathway | |||
4 | B cell activation | |||
5 | EGF receptor signaling pathway | |||
6 | Endothelin signaling pathway | |||
7 | FGF signaling pathway | |||
8 | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||
9 | Inflammation mediated by chemokine and cytokine signaling pathway | |||
10 | Metabotropic glutamate receptor group I pathway | |||
11 | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||
12 | VEGF signaling pathway | |||
13 | Wnt signaling pathway | |||
14 | 5HT2 type receptor mediated signaling pathway | |||
15 | Histamine H1 receptor mediated signaling pathway | |||
16 | Oxytocin receptor mediated signaling pathway | |||
17 | Thyrotropin-releasing hormone receptor signaling pathway | |||
18 | CCKR signaling map ST | |||
Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | Click to Show/Hide | ||
2 | TCR signaling in naï | |||
3 | ||||
4 | TCR signaling in naï | |||
5 | ||||
6 | IL2-mediated signaling events | |||
7 | Ras signaling in the CD4+ TCR pathway | |||
8 | JNK signaling in the CD4+ TCR pathway | |||
9 | Regulation of Ras family activation | |||
10 | Downstream signaling in naï | |||
Reactome | Disinhibition of SNARE formation | Click to Show/Hide | ||
2 | Activation of NF-kappaB in B cells | |||
3 | Trafficking of GluR2-containing AMPA receptors | |||
4 | G alpha (z) signalling events | |||
5 | Depolymerisation of the Nuclear Lamina | |||
6 | WNT5A-dependent internalization of FZD4 | |||
7 | VEGFR2 mediated cell proliferation | |||
8 | Response to elevated platelet cytosolic Ca2+ | |||
WikiPathways | Calcium Regulation in the Cardiac Cell | Click to Show/Hide | ||
2 | Insulin Signaling | |||
3 | EGF/EGFR Signaling Pathway | |||
4 | Wnt Signaling Pathway | |||
5 | Wnt Signaling Pathway and Pluripotency | |||
6 | MAPK Signaling Pathway | |||
7 | Wnt Signaling Pathway Netpath | |||
8 | G Protein Signaling Pathways | |||
9 | Kit receptor signaling pathway | |||
10 | Myometrial Relaxation and Contraction Pathways | |||
11 | Signaling by the B Cell Receptor (BCR) | |||
12 | Oncostatin M Signaling Pathway | |||
13 | Corticotropin-releasing hormone | |||
14 | AGE/RAGE pathway | |||
15 | B Cell Receptor Signaling Pathway | |||
16 | Signaling Pathways in Glioblastoma | |||
17 | miRs in Muscle Cell Differentiation | |||
18 | Response to elevated platelet cytosolic Ca2+ | |||
19 | MicroRNAs in cardiomyocyte hypertrophy | |||
20 | Physiological and Pathological Hypertrophy of the Heart |