Natural Product (NP) Details
| General Information of the NP (ID: NP1614) | |||||
|---|---|---|---|---|---|
| Name |
Corticosteroid
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| Species Origin | Homo sapiens ... | Click to Show/Hide | |||
| Homo sapiens | |||||
| Disease | Digestive system disease [ICD-11: DE2Z] | Preclinical | [1] | ||
| TTD Drug ID | |||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| Cyclosporin | Psoriasis vulgaris | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| In-vivo Model | Clinical trial | |||||
| Experimental
Result(s) |
Triple immunosuppressive therapy significantly reduced proteinuria and preserved renal function in refractory NS patients. | |||||
| Target and Pathway | ||||
|---|---|---|---|---|
| Target(s) | Estrogen-related receptor-alpha (ESRRA) | Molecule Info | [3] | |
| Reactome | PPARA activates gene expression | Click to Show/Hide | ||
| 2 | Transcriptional activation of mitochondrial biogenesis | |||
| 3 | Nuclear Receptor transcription pathway | |||
| WikiPathways | Mitochondrial Gene Expression | Click to Show/Hide | ||
| 2 | Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |||
| 3 | Nuclear Receptors | |||
