Natural Product (NP) Details
General Information of the NP (ID: NP6711) | |||||
---|---|---|---|---|---|
Name |
Glucocorticoids
|
||||
Species Origin | Homo sapiens ... | Click to Show/Hide | |||
Homo sapiens | |||||
Disease | Thyrotoxicosis [ICD-11: 5A02] | Phase 3 | [1] |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
---|---|---|---|---|---|---|
α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
Selumetinib | Melanoma | Click to Show/Hide the Molecular Data of This Drug | ||||
Achieving Therapeutic Synergy | Click to Show/Hide | |||||
Representative Experiment Reporting the Effect of This Combination | [2] | |||||
Detail(s) | Combination Info click to show the detail info of this combination | |||||
Molecule(s)
Regulation |
Up-regulation | Expression | BCL2L11 | Molecule Info |
Pathway MAP
|
|
Down-regulation | Phosphorylation | ERK1 | Molecule Info |
Pathway MAP
|
||
In-vitro Model | Cells derived from acute lymphoblastic leukemia patients | Acute lymphoblastic leukemia | Homo sapiens | |||
In-vivo Model | For a xenograft model, primagraft cells were injected intrafemorally into NOD SCID Gamma null (NSG) mice. | |||||
Experimental
Result(s) |
A selumetinib-dexamethasone combination may be highly effective in RAS pathway-mutated acute lymphoblastic leukemia. |