Natural Product (NP) Details
General Information of the NP (ID: NP7818) | |||||
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Name |
Morroniside
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Synonyms |
Morroniside; 25406-64-8; CHEBI:80852; (7Beta-Hydroxy)-Morroniside; methyl (1S,3R,4aS,8S,8aS)-3-hydroxy-1-methyl-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,3,4,4a,8,8a-hexahydropyrano[3,4-c]pyran-5-carboxylate; CHEMBL1209803; DTXSID60948257; HY-N0532; BDBM50279531; s5465; ZINC56874303; AKOS027250775; CCG-268714; AS-56291; CS-0009065; C17000; Q27151347; (1S)-1alpha-(beta-D-Glucopyranosyloxy)-6alpha-hydroxy-8beta-methyl-4aalpha,5,8,8aalpha-tetrahydro-1H,6H-pyrano[3,4-c]pyran-4-carboxylic acid methyl ester; Methyl 8-(hexopyranosyloxy)-3-hydroxy-1-methyl-4,4a,8,8a-tetrahydro-1H,3H-pyrano[3,4-c]pyran-5-carboxylate
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Species Origin | Cornus officinalis ... | Click to Show/Hide | |||
Cornus officinalis | |||||
Disease | Myocardial infarction [ICD-11: BA41] | Investigative | [1] | ||
Structure |
Click to Download Mol2D MOL |
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Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | |||||
Formula |
C17H26O11
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PubChem CID | |||||
Canonical SMILES |
CC1C2C(CC(O1)O)C(=COC2OC3C(C(C(C(O3)CO)O)O)O)C(=O)OC
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InChI |
1S/C17H26O11/c1-6-11-7(3-10(19)26-6)8(15(23)24-2)5-25-16(11)28-17-14(22)13(21)12(20)9(4-18)27-17/h5-7,9-14,16-22H,3-4H2,1-2H3/t6-,7+,9+,10+,11+,12+,13-,14+,16-,17-/m0/s1
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InChIKey |
YTZSBJLNMIQROD-SFBCHFHNSA-N
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CAS Number |
CAS 25406-64-8
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SymMap ID |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
Diosgenin | Hepatocellular carcinoma | Click to Show/Hide the Molecular Data of This Drug | ||||
Achieving Therapeutic Synergy | Click to Show/Hide | |||||
Representative Experiment Reporting the Effect of This Combination | [2] | |||||
Detail(s) | Combination Info click to show the detail info of this combination | |||||
Molecule(s)
Regulation |
Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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Experimental
Result(s) |
Combination of morroniside and diosgenin prevents high glucose-induced cardiomyocytes apoptosis. |
Target and Pathway | ||||
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Target(s) | Glucagon-like peptide 1 receptor (GLP1R) | Molecule Info | [3] | |
KEGG Pathway | cAMP signaling pathway | Click to Show/Hide | ||
2 | Neuroactive ligand-receptor interaction | |||
3 | Insulin secretion | |||
Reactome | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | Click to Show/Hide | ||
2 | G alpha (s) signalling events | |||
3 | Glucagon-type ligand receptors | |||
WikiPathways | GPCRs, Class B Secretin-like | Click to Show/Hide | ||
2 | Integration of energy metabolism | |||
3 | GPCR ligand binding | |||
4 | GPCR downstream signaling |