Natural Product (NP) Details
General Information of the NP (ID: NP9032) | |||||
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Name |
Allicin
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Synonyms |
Diallyl thiosulfinate; Diallyldisulfid-S-oxid; Thio-2-propene-1-sulfinic acid S-allyl ester; S-Allyl acrylo-1-sulphinothioate; Allylthiosulphinic acid allyl ester; DADSO; S-allyl prop-2-ene-1-sulfinothioate; diallyl disulfide-oxide; S-allyl 2-propene-1-sulfinothioate; C6H10OS2; CCRIS 9053; EINECS 208-727-7; 2-Propene-1-sulfinothioic acid, S-2-propenyl ester; BRN 1752823; 3-prop-2-enylsulfinylsulfanylprop-1-ene; CHEMBL359965; CHEBI:28411; 3-allylsulfinylsulfanylprop-1-ene; 2-Propene-1-sulfinic acid, thio-, S-; 539-86-6
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Species Origin | Allium fistulosum ... | Click to Show/Hide | |||
Allium fistulosum | |||||
Disease | Alveolar echinococcosis [ICD-11: 1F73] | Investigative | [1] | ||
Structure |
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Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | |||||
Formula |
C6H10OS2
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PubChem CID | |||||
Canonical SMILES |
C=CCSS(=O)CC=C
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InChI |
1S/C6H10OS2/c1-3-5-8-9(7)6-4-2/h3-4H,1-2,5-6H2
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InChIKey |
JDLKFOPOAOFWQN-UHFFFAOYSA-N
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CAS Number |
CAS 539-86-6
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TTD Drug ID |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
5-fluorouracil | Solid tumour/cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
Augmenting Drug Sensitivity | Click to Show/Hide | |||||
Representative Experiment Reporting the Effect of This Combination | [2] | |||||
Detail(s) | Combination Info click to show the detail info of this combination | |||||
Biological
Regulation |
Induction | Loss of mitochondrial membrane potential | ||||
Up-regulation | ROS generation | |||||
In-vitro Model | SK-HEP-1 | CVCL_0525 | Hepatocellular carcinoma | Homo sapiens | ||
BEL-7402 | CVCL_5492 | Human hepatocellular carcinoma | Homo sapiens | |||
In-vivo Model | Male athymic nude mice (4-6-week) were injected subcutaneously into left flank with 1*107 GFP-SK-Hep-1 cells. | |||||
Experimental
Result(s) |
Allicin sensitizes hepatocellular cancer cells to anti-tumor activity of 5-fluorouracil through ROS-mediated mitochondrial pathway. |
Target and Pathway | ||||
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Target(s) | Cysteine protease (CYP) | Molecule Info | [3] |