Molecule Details
General Information of the Molecule | ||||
---|---|---|---|---|
Name |
Aquaporin-4 (AQP4)
|
|||
Synonyms |
AQP-4; Mercurial-insensitive water channel; MIWC; WCH4; ATP-binding cassette sub-family C member 10
|
|||
Gene Name |
AQP4
|
|||
Gene ID | ||||
Sequence |
MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG
GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH VIDVDRGEEKKGKDQSGEVLSSV Click to Show/Hide
|
|||
Function |
Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity).
Click to Show/Hide
|
|||
Uniprot ID | ||||
TC Number | ||||
Pfam | ||||
KEGG ID |
Natural Product(s) of This Target | ||||
---|---|---|---|---|
1 | Gamabufotalin | NP Info | Investigative | Andrias davidianus |