Molecule Details
General Information of the Molecule | ||||
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Name |
Eukaryotic translation initiation factor 2A (EIF2A)
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Synonyms |
eIF-2A; 65 kDa eukaryotic translation initiation factor 2A; Basic leucine zipper transcriptional factor ATF-like 2
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Gene Name |
EIF2A
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Gene ID | ||||
Sequence |
MAPSTPLLTVRGSEGLYMVNGPPHFTESTVFPRESGKNCKVCIFSKDGTLFAWGNGEKVN
IISVTNKGLLHSFDLLKAVCLEFSPKNTVLATWQPYTTSKDGTAGIPNLQLYDVKTGTCL KSFIQKKMQNWCPSWSEDETLCARNVNNEVHFFENNNFNTIANKLHLQKINDFVLSPGPQ PYKVAVYVPGSKGAPSFVRLYQYPNFAGPHAALANKSFFKADKVTMLWNKKATAVLVIAS TDVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKAT IFNLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDS TYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSILHKYDVPSNAELWQVSWQPFLDGI FPAKTITYQAVPSEVPNEEPKVATAYRPPALRNKPITNSKLHEEEPPQNMKPQSGNDKPL SKTALKNQRKHEAKKAAKQEARSDKSPDLAPTPAPQSTPRNTVSQSISGDPEIDKKIKNL KKKLKAIEQLKEQAATGKQLEKNQLEKIQKETALLQELEDLELGI Click to Show/Hide
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Function |
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
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Uniprot ID | ||||
Pfam | ||||
KEGG ID |
Natural Product(s) of This Target | ||||
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1 | 6-shogaol | NP Info | Investigative | Acacia confusa |
References | ||||
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Reference 1 | 6-Shogaol induces apoptosis in human leukemia cells through a process involving caspase-mediated cleavage of eIF2Alpha. Mol Cancer. 2013 Nov 12;12(1):135. |