Molecule Details
General Information of the Molecule | ||||
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Name |
Transcription factor E2F
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Synonyms |
The E2 factor of transcription factor
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Function |
E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as suppressors: E2F3b, E2F4-8. All of them are involved in the cell cycle regulation and synthesis of DNA in mammalian cells. E2Fs as TFs bind to the TTTCCCGC (or slight variations of this sequence) consensus binding site in the target promoter sequence.
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Uniprot ID |
NOUNIPROTAC
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Drug(s) of This Target | ||||
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1 | Anti-CD4 (GK1.5) antibody | Drug Info | Phase 2 | Melanoma |
References | ||||
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Reference 1 | E2F inhibition synergizes with paclitaxel in lung cancer cell lines. PLoS One. 2014 May 15;9(5):e96357. |