Molecule Details
General Information of the Molecule | ||||
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Name |
Jun N terminal kinase (JNK)
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Synonyms |
c-Jun N-terminal kinase; Stress-activated protein kinase JNK; SAPK1; PRKM; MAP kinase; JNK
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Gene Name |
MAPK8; MAPK9; MAPK10
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Function |
Associates with scaffold proteins JNK interacting proteins as well as their upstream kinases JNKK1 and JNKK2 following their activation. Modifies the activity of numerous proteins that reside at the mitochondria or act in the nucleus. Downstream molecules that are activated by JNK include c-Jun, ATF2, ELK1, SMAD4, p53 and HSF1. Involved in apoptosis, neurodegeneration, cell differentiation and proliferation, inflammatory conditions and cytokine production mediated by AP-1 (activation protein 1) such as RANTES, IL-8 and GM-CSF.
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Uniprot ID | ||||
TTD ID |
Drug(s) of This Target | ||||
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1 | SP600125 | Drug Info | Investigative | Chronic kidney disease |
References | ||||
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Reference 1 | c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest. 2001 Jul;108(1):73-81. |