Molecule Details
General Information of the Molecule | ||||
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Name |
Nuclear factor erythroid 2-related factor 2 (Nrf2)
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Synonyms |
Nuclear factor, erythroid derived 2, like 2; NRF2; NFE2-related factor 2; NF-E2-related factor 2; HEBP1
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Gene Name |
NFE2L2
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Gene ID | ||||
Sequence |
MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQE
QLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCM QLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGM QQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVG NCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMP SPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHS VESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDA QCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVD FNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLL KEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKP DVKKN Click to Show/Hide
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Function |
Important for the coordinated up-regulation of genes in response to oxidative stress and the regulation of cellular redox conditions. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes.
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Uniprot ID | ||||
Pfam | ||||
KEGG ID | ||||
TTD ID |
Natural Product(s) of This Target | ||||
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1 | Brusatol | NP Info | Investigative | Brucea javanica |
2 | Cucurbitacin I | NP Info | Investigative | Citrullus lanatus |
3 | Daphnetin | NP Info | Investigative | Euphorbia |
4 | Ginsenoside Rh2 | NP Info | Investigative | Panax ginseng |
5 | Isoliquiritigenin | NP Info | Investigative | Robinia pseudoacacia |
6 | Lycopene | NP Info | Phase 2 | Daucus carota |
7 | Neferine | NP Info | Investigative | Nelumbo nucifera |
8 | Oridonin | NP Info | Investigative | Isodon rubescens |
9 | Polydatin | NP Info | Investigative | Polygonum cuspidatum |
10 | Salvianolic acid A | NP Info | Investigative | Salvia |
11 | Xanthohumol | NP Info | Investigative | Humulus lupulus |
Drug(s) of This Target | ||||
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1 | Diazinon | Drug Info | Investigative | Scabies |
2 | MST312 | Drug Info | Investigative | Lung cancer |