Molecule Details
General Information of the Molecule | ||||
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Name |
Rhodopsin (RHO)
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Synonyms |
Opsin-2; OPN2
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Gene Name |
RHO
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Gene ID | ||||
Sequence |
MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLY
VTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLG GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIP EGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQES ATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAI YNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA Click to Show/Hide
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Function |
Required for photoreceptor cell viability after birth. Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. Photoreceptor required for image-forming vision at low light intensity.
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Uniprot ID | ||||
TC Number | ||||
Pfam | ||||
TTD ID |
Natural Product(s) of This Target | ||||
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1 | Palmitic acid | NP Info | Investigative | Myrmecophilus sp. palM |
References | ||||
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Reference 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |