Drug Combination Details
General Information of the Combination (ID: C17243) | |||||
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Name | Apigenin NP Info | + | Gefitinib Drug Info | ||
Structure | + | ||||
Disease |
Lung cancer
[ICD-11: 2C25]
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Investigative | [1] |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. Enhancing Drug Efficacy by This Combination | ||||||
Augmenting Drug Sensitivity | Click to Show/Hide | |||||
Experiment 1 Reporting the Effect of This Combination | [1] | |||||
Molecule(s)
Regulation |
Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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Up-regulation | Expression | BCL2L11 | Molecule Info |
Pathway MAP
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Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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Down-regulation | Expression | CYB5R2 | Molecule Info |
Pathway MAP
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Down-regulation | Expression | CYM | Molecule Info |
Pathway MAP
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Down-regulation | Expression | HIF-1A | Molecule Info |
Pathway MAP
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Down-regulation | Expression | MYC | Molecule Info |
Pathway MAP
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Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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Down-regulation | Phosphorylation | PRKAA1 | Molecule Info |
Pathway MAP
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Down-regulation | Expression | SLC2A1 | Molecule Info |
Pathway MAP
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Down-regulation | Expression | SLC2A3 | Molecule Info |
Pathway MAP
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Down-regulation | Expression | SLC2A4 | Molecule Info |
Pathway MAP
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Biological
Regulation |
Down-regulation | Autophagy flux | ||||
Induction | Cell cycle arrest in G0/G1 phase | |||||
In-vitro Model | NCI-H1975 | CVCL_1511 | Lung adenocarcinoma | Homo sapiens | ||
Experimental
Result(s) |
Apigenin combined with gefitinib blocks autophagy flux and induces apoptotic cell death through inhibition of HIF-1alpha, c-Myc, p-EGFR, and glucose metabolism in EGFR L858R+T790M-mutated H1975 Cells. |