Drug Combination Details
General Information of the Combination (ID: C80432) | |||||
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Name | Genistein NP Info | + | Terazosin Drug Info | ||
Structure | + | ||||
Disease |
Prostate cancer
[ICD-11: 2C82]
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Investigative | [1] |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. Enhancing Drug Efficacy by This Combination | ||||||
Achieving Therapeutic Synergy | Click to Show/Hide | |||||
Experiment 1 Reporting the Effect of This Combination | [1] | |||||
Molecule(s)
Regulation |
Down-regulation | Expression | BCL-xL | Molecule Info |
Pathway MAP
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Down-regulation | Expression | NRP1 | Molecule Info |
Pathway MAP
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In-vitro Model | DU145 | CVCL_0105 | Prostate carcinoma | Homo sapiens | ||
Experimental
Result(s) |
The terazosin/genistein combination was more effective in inhibiting cell growth and VEGF expression as well as inducing apoptosis of the metastatic, androgen-independent prostate cancer cell line, DU-145, than either alone. |
References | ||||
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Reference 1 | Combined effects of terazosin and genistein on a metastatic, hormone-independent human prostate cancer cell line. Cancer Lett. 2009 Apr 8;276(1):14-20. |