Drug Combination Details
| General Information of the Combination (ID: C89396) | |||||
|---|---|---|---|---|---|
| Name | Ergosterol NP Info | + | Amphotericin B Drug Info | ||
| Structure |
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+ |
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| Disease |
Hepatocellular carcinoma
[ICD-11: 2C12]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Biological
Regulation |
Disruption | Cell membrane integrity | ||||
| In-vitro Model | Hep 3B2.1-7 | CVCL_0326 | Childhood hepatocellular carcinoma | Homo sapiens | ||
| HepJ5 | CVCL_RW48 | Hepatoblastoma | Homo sapiens | |||
| Experimental
Result(s) |
Combination treatment of ergosterol followed by amphotericin B induces necrotic cell death in human hepatocellular carcinoma cells. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Combination treatment of ergosterol followed by amphotericin B induces necrotic cell death in human hepatocellular carcinoma cells. Oncotarget. 2017 Aug 16;8(42):72727-72738. | |||
