Natural Product (NP) Details
| General Information of the NP (ID: NP7824) | |||||
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| Name |
Ergosterol
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| Species Origin | Homo sapiens ... | Click to Show/Hide | |||
| Homo sapiens | |||||
| Disease | Chronic kidney disease [ICD-11: GB61] | Investigative | [1] | ||
| Structure |
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Click to Download Mol2D MOL |
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| Formula |
C28H44O
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| Canonical SMILES |
CC(C)C(C)C=CC(C)C1CCC2C1(CCC3C2=CC=C4C3(CCC(C4)O)C)C
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| InChI |
1S/C28H44O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-10,18-20,22,24-26,29H,11-17H2,1-6H3/b8-7+/t19-,20+,22-,24+,25-,26-,27-,28+/m0/s1
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| InChIKey |
DNVPQKQSNYMLRS-APGDWVJJSA-N
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| CAS Number |
CAS 57-87-4
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| ChEBI ID | |||||
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| SymMap ID | |||||
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| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| Amphotericin B | Fungal infection | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Biological
Regulation |
Disruption | Cell membrane integrity | ||||
| In-vitro Model | Hep 3B2.1-7 | CVCL_0326 | Childhood hepatocellular carcinoma | Homo sapiens | ||
| HepJ5 | CVCL_RW48 | Hepatoblastoma | Homo sapiens | |||
| Experimental
Result(s) |
Combination treatment of ergosterol followed by amphotericin B induces necrotic cell death in human hepatocellular carcinoma cells. | |||||
