Natural Product (NP) Details
General Information of the NP (ID: NP1023) | |||||
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Name |
Morin
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Synonyms |
Aurantica; Calico Yellow; Al-Morin; Toxylon Pomiferum; Morin hydrate; 2',3,4',5,7-Pentahydroxyflavone; 2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one; Bois d,Arc; Osage Orange; Osage Orange Extract; Bois d'arc; C.I. Natural Yellow 11; C.I. Natural Yellow 8; Osage Orange Crystals; 3,5,7,2',4'-Pentahydroxyflavone; 3,5,7,2',4'-Pentahydroxyflavonol; 2'-Hydroxypelargidenolon 1522; 2',4',3,5,7-Pentahydroxyflavone; C.I. 75660; Zlut prirodni 11; 2',4',5,7-Tetrahydroxyflavan-3-ol; Bois d'arc [French]
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Species Origin | Morus serrata ... | Click to Show/Hide | |||
Morus serrata | |||||
Garcinia multiflora | |||||
Garcinia morella | |||||
Disease | Acute lymphoblastic leukemia [ICD-11: 2B33] | Investigative | [1] | ||
Structure |
Click to Download Mol2D MOL |
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Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | |||||
Formula |
C15H10O7
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PubChem CID | |||||
Canonical SMILES |
C1=CC(=C(C=C1O)O)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O
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InChI |
1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H
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InChIKey |
YXOLAZRVSSWPPT-UHFFFAOYSA-N
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CAS Number |
CAS 480-16-0
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Herb ID | |||||
ETMC ID | |||||
SymMap ID | |||||
TCMSP ID | |||||
TTD Drug ID |
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
MST312 | Lung cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
Augmenting Drug Sensitivity | Click to Show/Hide | |||||
Representative Experiment Reporting the Effect of This Combination | [2] | |||||
Detail(s) | Combination Info click to show the detail info of this combination | |||||
Molecule(s)
Regulation |
Down-regulation | Phosphorylation | STAT3 | Molecule Info |
Pathway MAP
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In-vitro Model | HT-29 | CVCL_0320 | Colon adenocarcinoma | Homo sapiens | ||
SW620 | CVCL_0547 | Colon adenocarcinoma | Homo sapiens | |||
MDA-MB-231 | CVCL_0062 | Breast adenocarcinoma | Homo sapiens | |||
Experimental
Result(s) |
Combination treatment with morin and telomerase inhibitor MST-312 reduces cancer stem cell traits by targeting STAT3 and telomerase. |
Target and Pathway | ||||
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Target(s) | Bcl-2-like protein 3 (MCL1) | Molecule Info | [3] | |
Fatty acid synthase (FASN) | Molecule Info | [4] | ||
Oestrogen receptor beta (ESR2) | Molecule Info | [3] | ||
Organic anion transporter 4-like (URAT1) | Molecule Info | [5] | ||
Plasmodium 3-oxoacyl-acyl-carrier reductase (Malaria fabG) | Molecule Info | [4] | ||
Plasmodium enoyl-ACP reductase (Malaria fabI) | Molecule Info | [4] | ||
Plasmodium Fatty acid synthesis protein (Malaria FabZ) | Molecule Info | [4] | ||
BioCyc | Fatty acid biosynthesis initiation | Click to Show/Hide | ||
2 | Fatty acid elongation -- saturated | |||
3 | Palmitate biosynthesis | |||
KEGG Pathway | PI3K-Akt signaling pathway | Click to Show/Hide | ||
2 | MicroRNAs in cancer | |||
3 | Fatty acid biosynthesis | |||
4 | Metabolic pathways | |||
5 | Fatty acid metabolism | |||
6 | AMPK signaling pathway | |||
7 | Insulin signaling pathway | |||
8 | Estrogen signaling pathway | |||
9 | Prolactin signaling pathway | |||
10 | Fatty acid biosynthesis | |||
11 | Biotin metabolism | |||
12 | Metabolic pathways | |||
13 | Fatty acid metabolism | |||
NetPath Pathway | TCR Signaling Pathway | Click to Show/Hide | ||
Panther Pathway | Apoptosis signaling pathway | Click to Show/Hide | ||
2 | CCKR signaling map ST | |||
Pathwhiz Pathway | Fatty Acid Biosynthesis | Click to Show/Hide | ||
Pathway Interaction Database | E2F transcription factor network | Click to Show/Hide | ||
2 | Direct p53 effectors | |||
3 | IL6-mediated signaling events | |||
4 | HIF-1-alpha transcription factor network | |||
5 | p73 transcription factor network | |||
6 | Validated transcriptional targets of deltaNp63 isoforms | |||
7 | Plasma membrane estrogen receptor signaling | |||
8 | Validated nuclear estrogen receptor beta network | |||
9 | Validated nuclear estrogen receptor alpha network | |||
Reactome | ChREBP activates metabolic gene expression | Click to Show/Hide | ||
2 | Activation of gene expression by SREBF (SREBP) | |||
3 | Fatty Acyl-CoA Biosynthesis | |||
4 | Nuclear Receptor transcription pathway | |||
WikiPathways | Apoptosis | Click to Show/Hide | ||
2 | miR-targeted genes in muscle cell - TarBase | |||
3 | miR-targeted genes in lymphocytes - TarBase | |||
4 | miR-targeted genes in leukocytes - TarBase | |||
5 | Apoptosis Modulation and Signaling | |||
6 | Fatty Acid Biosynthesis | |||
7 | Nuclear Receptors Meta-Pathway | |||
8 | Liver X Receptor Pathway | |||
9 | Activation of Gene Expression by SREBP (SREBF) | |||
10 | SREBF and miR33 in cholesterol and lipid homeostasis | |||
11 | SREBP signalling | |||
12 | Metabolism of water-soluble vitamins and cofactors | |||
13 | Integration of energy metabolism | |||
14 | Fatty acid, triacylglycerol, and ketone body metabolism | |||
15 | AMPK Signaling | |||
16 | SIDS Susceptibility Pathways | |||
17 | Ovarian Infertility Genes | |||
18 | Integrated Pancreatic Cancer Pathway | |||
19 | Nuclear Receptors | |||
20 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |