Drug Combination Details
| General Information of the Combination (ID: C00670) | |||||
|---|---|---|---|---|---|
| Name | Milrinone NP Info | + | Sildenafil Drug Info | ||
| Structure |
|
+ |
|
||
| Disease |
Myocardial infarction
[ICD-11: BA41]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | Male Wistar rat hearts were isolated using an in vitro Langendorff system. | |||||
| Experimental
Result(s) |
Treatment with sildenafil and milrinone in lower concentrations had an equally strong cardioprotective effect regarding infarct size reduction compared with the administration of "protective" concentrations. | |||||
