Drug Combination Details
| General Information of the Combination (ID: C02284) | |||||
|---|---|---|---|---|---|
| Name | Idebenone NP Info | + | Rasagiline Drug Info | ||
| Structure |
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+ |
|
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| Disease |
Retinopathy
[ICD-11: 9B78]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | DICER1 | Molecule Info |
Pathway MAP
|
|
| Up-regulation | Expression | Lin-28A | Molecule Info | |||
| Up-regulation | Expression | LIN28B | Molecule Info | |||
| Down-regulation | Expression | microRNA let-7a-3 | Molecule Info |
Pathway MAP
|
||
| Experimental
Result(s) |
Combination therapy with rasagiline and idebenone produced a synergistic effect that ameliorated RIR injury, restored visual function and provided neuroprotection. | |||||
