Drug Combination Details
| General Information of the Combination (ID: C02627) | |||||
|---|---|---|---|---|---|
| Name | Genistein NP Info | + | Tiazofurin Drug Info | ||
| Structure |
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+ |
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| Disease |
Acute lymphoblastic leukemia
[ICD-11: 2B33]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Biological
Regulation |
Induction | Cell differentiation | ||||
| In-vitro Model | K-562 | CVCL_0004 | Chronic myelogenous leukemia | Homo sapiens | ||
| Experimental
Result(s) |
Tiazofurin and genistein showed synergistic action on growth inhibition and differentiation of K-562 human leukemic cells. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic action of tiazofurin and genistein on growth inhibition and differentiation of K-562 human leukemic cells. Life Sci. 1998;63(22):1975-81. | |||
